Wegovy vs. Zepbound: Comparing Your Options
Brand-Name GLP-1 Medications for Weight Loss
Wegovy (semaglutide) and Zepbound (tirzepatide) are the two leading FDA-approved GLP-1 medications specifically for weight loss. Here is how they compare.
Key Differences
- Mechanism: Wegovy targets GLP-1 only. Zepbound targets both GLP-1 and GIP.
- Weight Loss: Zepbound shows ~22% average weight loss vs. ~15% for Wegovy in their respective trials.
- Insurance Coverage: Wegovy has been on the market longer and may have broader insurance coverage. Zepbound coverage is growing.
- Availability: Both have experienced shortages. Availability fluctuates — your provider can advise on current status in Charlotte.
- Cost: Similar list prices. Your out-of-pocket cost depends entirely on your insurance plan.
What Charlotte Providers Say
Local weight management providers generally offer both medications and help patients navigate insurance coverage, prior authorizations, and availability. The best medication is the one you can access consistently and tolerate well.